Tigers Host Guardians in Pivotal Three-Game Series as Mize Faces Cantillo in Tonight’s AL Central Showdown

DETROIT — As the clock struck 12:27 PM EDT on Tuesday, September 16, 2025, the Detroit Tigers’ Comerica Park buzzed with anticipation for a critical three-game series against the Cleveland Guardians, kicking off tonight at 6:40 PM ET. With the AL Central race tightening, this matchup pits Tigers ace Casey Mize (14-5) against Guardians starter Joey Cantillo (5-3) in a clash that could shape the postseason landscape. Broadcast live on FDSDET and 97.1 FM The Ticket, the series opener promises high stakes and electric moments for a city hungry for October baseball.

Mize, the 28-year-old right-hander, has been the Tigers’ backbone this season, boasting a 2.89 ERA and a career-high 14 wins. His resurgence after Tommy John surgery has fueled Detroit’s surprising 84-61 record, keeping them in contention for the division title. Tonight, he faces Cantillo, a 25-year-old lefty who has emerged as Cleveland’s bright spot with a 3.45 ERA and steady outings. The Guardians, at 86-59, hold a slim lead, making this series a must-win for both teams. “This is where seasons are decided,” Tigers manager A.J. Hinch said. “Casey’s ready to set the tone.”

The buildup has been intense. Detroit returns home after a grueling road trip, their bullpen taxed but their spirit unbroken. Mize’s recent dominance—three straight quality starts—gives the Tigers confidence, while Cantillo’s ability to limit hard contact has kept Cleveland’s rotation afloat. The matchup pits Mize’s power sinker against Cantillo’s deceptive changeup, a duel that could hinge on execution. “Joey’s been lights out,” Guardians skipper Stephen Vogt said. “But Mize is a different challenge.”

Fans are already flocking to Comerica Park, with tickets scarce and tailgates in full swing. The Tigers’ 2025 turnaround, led by Mize, Spencer Torkelson’s resurgence, and a stout defense, has reignited a fanbase that endured lean years. Cleveland, riding a balanced attack and a top-tier bullpen, aims to solidify its position. A sweep could clinch the division for the Guardians, while a Tigers victory could shift momentum decisively. “This feels like a playoff game,” said season-ticket holder Mark Rivera outside the stadium. “The energy’s unreal.”

The series carries extra weight with the postseason just weeks away. Detroit’s wild-card hopes hinge on this stretch, while Cleveland seeks to avoid a late-season collapse. Mize, a 2020 first-round pick, has embraced the spotlight, posting on X, “Time to lock in. Let’s go Detroit!” Cantillo, a 2021 draftee, counters with quiet confidence, his 5-3 record masking his impact on a Guardians staff hit by injuries.

As night falls, the first pitch will mark a turning point. With temperatures dipping into the low 60s and a sold-out crowd expected, the atmosphere will be electric. The Tigers’ lineup, featuring Torkelson and Riley Greene, faces a Guardians defense anchored by José Ramírez. For Mize and Cantillo, this is a chance to shine on a national stage. With the AL Central title on the line, tonight’s showdown at Comerica Park could echo through October.